Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.

نویسندگان

  • Cristina Rueda
  • Soledad Fenoy
  • Fernando Simón
  • Carmen Del Aguila
چکیده

The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 3  شماره 

صفحات  -

تاریخ انتشار 2008